Italian Sub Grilled Cheese

Featured in: Global Comforts

This Italian Sub Grilled Cheese brings together classic Italian cold cuts, creamy provolone, and a zesty lettuce mixture grilled between buttered bread. Salami and pepperoni layer with melted cheese for authentic flavor, topped with iceberg lettuce tossed in a tangy vinaigrette. Grill until the bread turns golden and cheese melts completely—about 3-4 minutes per side. Perfect for lunch or dinner, ready in just 20 minutes with simple pantry ingredients.

Updated on Tue, 20 Jan 2026 11:09:00 GMT
Golden-brown Italian Sub Grilled Cheese sandwich on a wooden board, melted provolone and savory cold cuts peeking from crispy bread with tangy lettuce topping.  Save
Golden-brown Italian Sub Grilled Cheese sandwich on a wooden board, melted provolone and savory cold cuts peeking from crispy bread with tangy lettuce topping. | munchhug.com

There was this tiny deli near my college apartment that made grinders so good people lined up in the rain for them. Years later, standing in my own kitchen with leftover salami and a craving I couldn't shake, I realized I could capture that same salty, tangy, melty magic in a grilled cheese. The butter hit the pan, the provolone started to bubble, and suddenly I was back in that cramped deli, except this time I was in control. It's become my go-to when I want comfort food that feels a little more exciting than the usual.

I made this for my brother one Sunday afternoon when he showed up unannounced and starving. He took one bite, paused, and said it tasted like the sandwich shop we used to sneak off to during high school lunch breaks. We ended up sitting at the counter for an hour, talking about nothing and everything, while he devoured both halves. That sandwich became our unofficial reunion meal whenever he visits now.

Ingredients

  • Italian bread or sturdy white sandwich bread: You need something with enough structure to hold up to grilling and all the fillings without falling apart, so avoid anything too soft or airy.
  • Unsalted butter, softened: Softened butter spreads evenly and creates that golden, crispy crust that makes grilled cheese irresistible.
  • Provolone cheese: It melts beautifully and has a mild, slightly tangy flavor that complements the salty meats without overpowering them.
  • Salami: Adds a rich, savory depth and a little bit of spice that anchors the whole sandwich.
  • Pepperoni: Brings a hint of smokiness and that classic Italian deli vibe we all crave.
  • Shredded iceberg lettuce: It stays crisp even after mixing with the dressing and provides a refreshing crunch that cuts through the richness.
  • Mayonnaise: Acts as the creamy base for the lettuce topping and helps everything cling together.
  • Red wine vinegar: Adds a bright, tangy punch that mimics the vinaigrette you'd find on a traditional sub.
  • Dried oregano: A little goes a long way in giving the sandwich that authentic Italian herb flavor.
  • Salt and freshly ground black pepper: Essential for balancing and enhancing all the other flavors.
  • Mild pepperoncini rings (optional): They add a gentle heat and a briny bite that makes the sandwich more interesting.
  • Thinly sliced red onion (optional): Provides a sharp, fresh contrast that brightens up the heavier ingredients.

Instructions

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Mix the Lettuce Topping:
In a bowl, toss together the shredded lettuce, mayonnaise, red wine vinegar, oregano, salt, and pepper until everything is evenly coated. This mixture should taste tangy and a little creamy, like the best part of a sub tucked into your sandwich.
Butter the Bread:
Lay out all four slices of bread and spread softened butter generously on one side of each. The butter is what turns the outside golden and crispy, so don't skimp here.
Layer the Fillings:
Place two slices of bread buttered side down on your work surface, then stack each with two slices of provolone, three slices of salami, and three slices of pepperoni. If you're using pepperoncini or red onion, scatter them on now for extra flavor.
Add the Lettuce Mix:
Spoon the lettuce mixture evenly over the meats and cheese, spreading it gently so it covers everything. This layer keeps the sandwich from feeling too heavy and adds a refreshing crunch.
Close the Sandwiches:
Top each sandwich with the remaining bread slices, buttered side up. Press down lightly so everything sticks together and the fillings settle in.
Grill Until Golden:
Heat a large skillet or grill pan over medium heat and place the sandwiches in the pan. Cook for three to four minutes per side, pressing gently with a spatula, until the bread is deeply golden and the cheese has melted into gooey perfection.
Slice and Serve:
Remove the sandwiches from the heat, let them rest for a moment, then slice each in half. Serve them hot while the cheese is still stretchy and the bread is crackling crisp.
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Season soups, salads, meats, and vegetables evenly while cooking with quick, one-handed grinding.
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A close-up of a buttery Italian Sub Grilled Cheese, grilled to perfection with melted cheese, salami, and pepperoni, served hot beside kettle chips.  Save
A close-up of a buttery Italian Sub Grilled Cheese, grilled to perfection with melted cheese, salami, and pepperoni, served hot beside kettle chips. | munchhug.com

One evening I packed these sandwiches up in foil and brought them to a friend's backyard hangout. Everyone was skeptical at first, expecting plain grilled cheese, but after the first bite the whole table went quiet. Someone finally said it tasted like the best deli sandwich they'd ever had, only better because it was warm and melty. That night this recipe earned a permanent spot in my entertaining lineup.

Choosing Your Bread

Italian bread is ideal because it has that slightly chewy texture and subtle flavor that lets the fillings shine. If you can't find it, a sturdy white sandwich bread works just fine, but avoid anything too soft or it will get soggy under the weight of the toppings. I've also tried this with sourdough and it added a nice tangy depth, though it can be a little harder to press flat. Whatever you choose, make sure it's thick enough to hold up to grilling without falling apart.

Making It Your Own

This sandwich is incredibly forgiving and loves a little improvisation. Swap the salami for capicola if you want something a bit spicier, or use mozzarella instead of provolone for a milder, stretchier melt. If you like heat, toss in some hot giardiniera or a few dashes of hot sauce into the lettuce mix. I've even added a smear of pesto on the inside before grilling, and it was incredible.

Serving and Pairing Ideas

These sandwiches are hearty enough to stand alone, but they're even better with a handful of kettle chips or a simple tomato salad on the side. I like to serve them with pickles and a cold drink, especially on a weekend afternoon when you want something satisfying without a lot of fuss. If you're feeding a crowd, double the recipe and keep the finished sandwiches warm in a low oven while you finish grilling the rest.

  • Serve with a tangy coleslaw or a handful of pickled vegetables for extra crunch.
  • Pair with a light beer or an iced tea to balance the richness of the cheese and meats.
  • Cut into smaller pieces and serve as an appetizer at your next game day gathering.
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Two halves of an Italian Sub Grilled Cheese stacked on a plate, showcasing layers of Italian cold cuts, provolone, and a zesty lettuce mixture. Save
Two halves of an Italian Sub Grilled Cheese stacked on a plate, showcasing layers of Italian cold cuts, provolone, and a zesty lettuce mixture. | munchhug.com

This sandwich has become my answer to boring lunches and last-minute cravings, proof that a little creativity and good ingredients can turn something simple into something you'll crave again and again. Make it once and I promise you'll keep coming back to it.

Recipe Guide

What bread works best for this sandwich?

Italian bread or sturdy white sandwich bread holds up best to grilling and melting cheese. You can substitute whole wheat or sourdough for different flavor profiles.

Can I add spice to this sandwich?

Yes, hot giardiniera or extra pepperoncini rings add a spicy kick. Red pepper flakes mixed into the lettuce mixture also work well for heat lovers.

How do I prevent the cheese from leaking out?

Press gently on the sandwich while grilling to help the cheese melt and bond with the bread. Don't press too hard or the fillings will squeeze out. Medium heat prevents the exterior from cooking too quickly.

What sides pair well with this sandwich?

Kettle chips, a crisp green salad, or a simple tomato salad complement the rich flavors. A pickle spear or coleslaw adds refreshing crunch.

Can I make this vegetarian?

Yes, omit the salami and pepperoni. Add roasted red peppers, sun-dried tomatoes, or marinated artichoke hearts for depth and texture instead.

How do I store leftovers?

Best enjoyed fresh off the grill, but leftovers can be refrigerated for up to 2 days in an airtight container. Reheat gently in a skillet over low heat to avoid drying out.

Italian Sub Grilled Cheese

Melty sandwich combining Italian cold cuts, provolone, and tangy lettuce topping grilled to golden perfection.

Prep duration
10 min
Heat time
10 min
Complete duration
20 min
Created by Samantha Reed


Skill level Easy

Heritage Italian-American

Output 2 Portions

Nutrition preferences None specified

Components

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper, to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

Method

Phase 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and freshly ground black pepper. Mix thoroughly and set aside.

Phase 02

Butter Bread Slices: Lay out all bread slices and spread one side of each slice evenly with softened unsalted butter.

Phase 03

Assemble Sandwich Base: Place two buttered bread slices buttered side down on a work surface. Top each slice with 2 slices of provolone cheese, 3 slices of salami, and 3 slices of pepperoni.

Phase 04

Add Optional Toppings: Distribute pepperoncini rings and sliced red onion over the meats and cheese if desired.

Phase 05

Layer Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese layer.

Phase 06

Complete Sandwich: Top each sandwich with remaining bread slices, buttered side up, to enclose the filling.

Phase 07

Grill Sandwich: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook for 3 to 4 minutes per side, pressing gently with a spatula, until bread is golden brown and cheese is fully melted.

Phase 08

Finish and Serve: Remove sandwiches from heat, slice diagonally in half, and serve immediately while hot.

Tools needed

  • Skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy alerts

Review ingredients carefully for potential allergens and seek professional medical guidance if concerned.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs in mayonnaise - verify specific brand composition
  • Contains pork from salami and pepperoni

Dietary info (per portion)

Values shown are estimates only - please consult healthcare providers for specific advice.
  • Energy: 540
  • Lipids: 34 g
  • Carbohydrates: 35 g
  • Proteins: 24 g